Evidence for ACTN3 as a Speed Gene in Isolated Human Muscle Fibers
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چکیده
منابع مشابه
Evidence for ACTN3 as a Speed Gene in Isolated Human Muscle Fibers
PURPOSE To examine the effect of α-actinin-3 deficiency due to homozygosity for the ACTN3 577X-allele on contractile and morphological properties of fast muscle fibers in non-athletic young men. METHODS A biopsy was taken from the vastus lateralis of 4 RR and 4 XX individuals to test for differences in morphologic and contractile properties of single muscle fibers. The cross-sectional area of...
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Over the last couple of decades, research has focused on attempting to understand the genetic influence on sports performance. This has led to the identification of a number of candidate genes which may help differentiate between elite and non-elite athletes. One of the most promising genes in that regard is ACTN3, which has commonly been referred to as "a gene for speed". Recent research has e...
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Background: Although maximal sprint speed (MSS) and the anaerobic speed reserve (ASR) provides valuable information about the speed profile of athletes, these parameters fall short of providing important information about sub-maximal metabolic thresholds. The only field test that can offer an estimate of a sub-maximal metabolic threshold is the 3-minute all-out test for running (3MT) which deli...
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A common variant of the ACTN3 gene, R577X, results in complete deficiency of the alpha-actinin-3 protein in the fast skeletal muscle fibers of more than a billion humans worldwide. We review the evidence that this genetic variant is strongly associated with elite athlete status and with normal variation in human muscle strength and sprinting speed.
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ژورنال
عنوان ژورنال: PLOS ONE
سال: 2016
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0150594